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Clinical trials with icatibant and ecallantide will be necessary to prove their efficacy and safety profile in this type of angioedema. Every author contributed to the manuscript. None of the authors have any conflict of interests. Clinical implications: Angioedema Type III, related to the F12 gene mutation, should be looked even in non-Caucasian patients. ""The food hypersensitivity reactions Otenabant frequently manifest as respiratory tract symptoms and asthma and food hypersensitivity often coexist. Food allergens are known to be a cause of occupational asthma. The coexistence of asthma is associated with anaphylaxis while the coexistence of food hypersensitivity increases the risk of a life-threatening exacerbation of asthma. Clinicians, therefore, need to take a holistic approach to managing both the patient's asthma and food hypersensitivity. ""We appreciate the positive attitude to our study. However, the primary intention was not to document the clinical effects of long-term Xolair treatment. There were indications that short-term treatment, i.e. Ribociclib a most interesting difference between low CD-sens and serum IgE antibody concentrations. Thus, there is a possibility that the inflammatory cells involved in IgE-mediated allergy, i.e. the mast cells and basophils, turn down their allergen responsiveness during long-term Xolair treatment. As many of our patients were given too low www.selleckchem.com/products/mi-773-sar405838.html doses of Xolair (4), it is possible that this effect could be achieved in much less than the 6?years in this study. We agree with the author that cat allergens are much easier to eliminate, and more studies regarding mite and other allergens are needed to fully understand the clinical effects of long-term Xolair treatment. However, the main reason for choosing cat in the mentioned study is that the majority of the patients were sensitized to that allergen. None of the patients got rid of their cat, and some patients even brought home new cats (many cats!) without any worsening of their asthma. Three of the included patients were mite sensitized, and they followed the same pattern as the cat-sensitized patients. However, because the idea behind allergen-specific immuno therapy is to expose the patients to high doses of allergen, the positive effect might be even more pronounced in patients with mite allergy. ""According to international figures, the prevalence rate of food hypersensitivity varies between 3.24% and 34.9% (1, 2).