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Fibrinogen concentrate (Haemocomplettan P 1?g?, CSL Behring, Marburg, Germany) is used to correct AZD6244 purchase low fibrinogen concentration and/or poor fibrin polymerisation (fibrinogen concentration??1.5 and/or EXTEM CT?>?90?s). FFP are transfused according to the clinical experience of the anaesthesiologist in charge and plasmatic coagulation test results (INR?>?1.5, aPTT?>?50?s). Aphaeresis platelet concentrates MDV3100 supplier are used in bleeding patients showing platelet counts Telomerase revealing a p-value?