The History Behind The Ulixertinib Achievements

3% and 38.2% respectively [14,15]. Similarly a higher percentage of the responding dentists in surveys done in USA, prescribed the antibiotics for similar condition [14,16]. Again, this is an unjustified and unnecessary antibiotic prescription because the justified treatment for this condition is the removal of the cause by nonsurgical endodontic treatment. The sixth endodontic condition of this survey was irreversible pulpitis with moderate/severe preoperative symptoms. In this condition the pulp is vital and there are no signs and symptoms of systemic involvement so there is no indication for the prescription of antibiotics in this condition [17]. In the present study 27.3% of the Responding dentists prescribed antibiotics for this condition which is totally unjustified and unnecessary. This finding in the present study showed that the scientific basis for the prescription of antibiotics in the present condition is neglected by a large percentage of the responding dentists. In the previous surveys done in Spain, India and US 31% and 37.6% of the responding dentists respectively prescribed the antibiotics for this condition, which are comparable with our study [14,15]. In the present study, [Table/Fig-3] shows the percentages of various types of antibiotics which have been prescribed by responding dentists. Amoxicillin and clavulanic acid in combination is considered as a combination of choice for odontogenic infection because this combination has the broad antimicrobial spectrum and low incidence of bacterial CASK resistance [18]. In the present survey the drug which was most prescribed by the responding dentists was amoxicillin and clavulanic acid combination 45.2 % followed by amoxicillin alone 33.7% and amoxicillin and metronidazole combination 15%. In a survey done by Spanish dentists amoxicillin in combination with calvulanic acid was prescribed by 61% of the respondents followed by amoxicillin. In 2007 the antibiotic treatment which has been prescribed by the Spanish dentists was amoxicillin and clavulanic acid, followed by amoxicillin alone [19]. Amoxicillin was a principal antimicrobial agent in the European countries [20]. Amoxicillin being broad spectrum is a drug of choice to treat the odontogenic infection, but it may cause antibiotic resistance [21]. In Contrast in the USA amoxicillin was prescribed only by 27.5% of members of AAE [14,16]. In the present survey, metronidazole was prescribed by the respondents as Falgyal and only a small percentage of the responding dentists prescribed it (5.7%). Metronidazole is very effective antimicrobial agent against obligate anaerobes but not as effective against facultative anaerobes.