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All main effects were significant (TDCS [F(2,22)?=?11.055, p?selleck out a series of one-sample t-tests (against zero) to test whether, within each TDCS condition, there was a significant change in the excitability of each hand (Fig.?1). Second, we decomposed the data by the factor of Hand, and conducted one-way RM ANOVAs, one per hand, to compare the relative efficacy of each TDCS condition in inducing a relative excitability increase in the right hand and/or a relative excitability decrease in the left hand. In the Anodal condition, as flupentixol expected, mean excitability of the contralateral (right) hand (Acontra) increased (t(12)?=?5.812, p?PFI-2 clinical trial (Ccontra) (t(12)?=???3.715, p?=?.003; M?=???21%, SD?=???19.9) accompanied by an increase in excitability of the ipsilateral (right) hand (Cipsi) (t(12)?=?2.917, p?=?.013; M?=?20%, SD?=?24.7). These two effects were not correlated (Pearson's R(13)?=?.698, p?=?.119). In the Bilateral condition, we hypothesized that the M1�CM1 electrode montage would increase excitability of the right hand (contralateral to the anode) and decrease excitability in the left hand (contralateral to the cathode). However, neither effect was significant (Right Hand: t(11)?=?1.818, p?=?.096; M?=?19.6%, SD?=?37.4; Left Hand: t(11)?=?.136, p?=?.895; M?=?1.5%, SD?=?37.1) or inter-correlated (p?=?.2). To test the relative efficacy of the three TDCS conditions, two one-way RM ANOVAs were conducted on the mean %��MEP data, one per hand. For the right hand, the pattern did not vary by electrode montage (F(2,22)?=?2.106, p?=?.