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5 are accepted as abnormal [16]), (iii) positive bacterial culture or serological test results for brucellosis in blood specimens (positive Rose Bengal selleckchem test (RBT) and serum tube agglutination (STA) with a titre ��1/160) or in CSF (positive RBT or STA with any titre) or positive bone marrow culture; and (iv) absence of an alternative neurological diagnosis explaining the clinical presentations. Patients fulfilling these criteria were regarded as having brucellar meningitis or meningoencephalitis and included in the study. The data analysis was performed with SPSS in the Windows V.15.0 program. Descriptive statistics were presented as frequencies, percentages for categorical variables and as mean?��?standard deviation and median (min�Cmax) for continuous variables. Before the analysis of titration data, logarithmic transformation (based on log10) was performed. In comparing the groups, the chi-square, Mann�CWhitney U and t-tests were used. The agreements between the tests were evaluated with Kappa coefficient. �� value?TRIB1 between the variables, Pearson and Spearman correlation coefficients were calculated. In comparing the sensitivity of the data, p?MK-2206 clinical trial and the sensitivities of the microbiological tests performed for the diagnosis are presented in Table?1. Serological tests such as serum-STA (n?=?172), CSF-STA (n?=?144), serum-RBT (n?=?123), CSF-RBT (n?=?106), CSF-Elisa (n?=?10) and serum-Elisa (n?=?11) were applied to our patients. In 100 cases, both STA and RBT tests were performed together in the CSF samples. The STA test was performed both in serum and in CSF in 141 cases and RBT was performed both in serum and in CSF in 104 cases. Among the eight serological tests applied (CSF-STA, CSF-RBT, serum-RBT, serum-STA, CSF IgM, CSF-IgG, serum IgM and Serum IgG), 32 (18.1%) patients had one, 45 (25.