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The Clinical Global Impression Severity (CGIS) scale is a 1-item (7 levels: 1 to 7) scale evaluating the severity of the syndrome from the clinician's perspective. The higher that the MADRS, PANSS, UKU, YMRS, and CGIS scores are, the greater is the severity or the adverse effects associated with the disorder. The EQ-5D [19] scale is a descriptive 5-item (3 BGJ398 molecular weight levels: 1 to 3) system of generic HRQoL states. The Short Form-6D (SF-6D) [20] scale is a 6-item (several levels) classification system also describing generic HRQoL. The higher that the EQ-5D and SF-6D scores are, the better the HRQoL reported by the patient. Because SF-6D Spanish social values are still not available and following the methodology proposed by Prieto and Sacristan [21], a nonweighted scoring rule based solely on the answers provided by the patients to both the SF-6D and the EQ-5D questionnaires was considered, thus eliminating the possible influence that social preferences may have on the scores. The nonweighted scores were also linearly transformed to the same scale as that of the weighted ones. The Paclitaxel cost Pearson correlation coefficients between the weighted and the nonweighted scores were SF-6D (0.94, P Fluconazole 2 weeks after the first visit, to assess the test-retest reliability of the utility estimates. After the fieldwork phase of the study, the collected sample included 243 (test) and 19 (retest) patients. To be included (or excluded) in the study, patients had to meet the following criteria: ? Inclusion criteria: willingness to participate in the study (signed informed consent form), 18 years old or older, diagnosis of schizophrenia or bipolar disorders according to the Diagnostic and Statistical Manual, Fourth Edition, receiving treatment with antipsychotic medication on a stable dose since at least the last month, ability to complete all the study procedures. All the scales and ratings proposed in the study were administered by the participant clinicians at the selected centers.