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Thank you DAPT molecular weight to Michelle Dion, David Hamel, Thierry Lafrance, Gabriel Kaufman, Rapha�lle Lambert, Barth�l�my Valteau, and Charlotte Zaouter for their technical assistance. This research project was funded by the Pediatric Orthopaedic Society of North America (POSNA), the FQRNT (Quebec, Canada), the NSERC (Canada), the Canada Research Chair in Mechanobiology of the Pediatric Musculoskeletal System (I.V.) and by Sainte-Justine UHC Foundation and the Foundation of Stars. ""Biomaterial-related infections continue to hamper the success of reconstructive and arthroplasty procedures in orthopaedic surgery. Staphylococci are the most common etiologic agents, with biofilm formation representing a major virulence factor. Biofilms increase bacterial resistance to antimicrobial agents and host immune responses. In staphylococci, production of polysaccharide intercellular adhesin (PIA) by the enzyme products of the icaADBC operon is the best understood mechanism of biofilm development, making the ica genes a potential target for biofilm inhibitors. In this study we report that the antibacterial agent povidone-iodine (PI) also has anti-biofilm activity against Staphylococcus epidermidis BML-190 and Staphylococcus aureus at sub-inhibitory concentrations (p?Doxorubicin supplier the icaR transcriptional repressor in Staphylococcus epidermidis. These data reveal an additional therapeutic benefit of PI and suggest that studies to evaluate suitability of PI as biomaterial coating agent to reduce device-related infections are merited. ? 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 28:1252�C1256, 2010 ""The purpose of this study was to investigate whether supraspinatus tendon failure stress at the footprint can increase by improving the bone density at the rotator cuff footprint in a rat model. Bilateral ovariectomies were performed in twenty-four 4-month-old Sprague-Dawley rats. Half received bisphosphonate (zoledronic acid) and the other half received no treatment (OVX?+?ZOM and OVX, respectively). Twelve additional rats did not undergo ovariectomy or receive bisphosphonate treatment (CON). All rats were sacrificed at 7 months of age. Quantitative micro-computed tomography was used to assess bone density in the proximal humerus. A series of stress�Crelaxation tests were performed to assess stiffness and failure stress of the supraspinatus tendon. Bone density in OVX?+?ZOM was significantly higher at the rotator cuff footprint when compared to CON and OVX rats (p?