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The secondary endpoints were changes in fasting blood glucose and high sensitive C-reactive protein (hsCRP). RESULTS From 102 patients, who came into the trial, 25 (24.5%) dropped out; hence, the final sample size was 77 (78.2%). Noncompliance with the study protocol (n = 21), drug intolerance (n = 2), and relocation (n = 2) were the reasons for the drop-out. We failed to find any significant difference (P > 0.05) when we compared the baseline data of biochemical and anthropometric factors before the first treatment period with those before the second treatment period. Thymidine kinase Moreover, no significant difference was found for age, sex, presence of hyperlipidemia, BMI, presence of hypertension, presence of diabetes, and smoking status between the two groups [Table 1]. Table 1 Comparison of baseline characteristics of subjects Effects of simvastatin versus placebo on Vitamin D Statin therapy did not have a significant effect on serum levels of Vitamin D in either the statin-placebo or the placebo-statin group [P = 0.90, Table 2]. Bivariate correlations were assessed between baseline values of Vitamin D and other evaluated biochemical parameters (total cholesterol, LDL-C, high-density lipoprotein cholesterol [HDL-C], triglycerides [TGs], FBG, and hs-CRP), as well as between changes in Vitamin D and other parameters during each study period. No significant correlation was found between baseline values of Vitamin D and evaluated biochemical parameters (P > 0.05) [Table ABT-737 order 3]. Furthermore, significant correlations were observed between serum Vitamin D and the following parameters: FBG (statin-placebo Nutlin-3 supplier group, second period; P first period; P