The Meaning Of BEZ235

[3,4] Organ failure support was provided as required. Blood sugar control was achieved with insulin infusion (Human Actrapid?). It was buy BLU9931 considered as ��favorable�� if the mean sugar levels were 6�C10 mmol/l/day and ��unfavorable�� if mean blood sugar levels were >10 mmol/l/day.[18] Status myoclonus was treated with sodium valproate and levetiracetam as first-line therapy with the addition of phenytoin or clonazepam as required. The use of midazolam and paralytics were reserved for severe status myoclonus unresponsive to the above measures. Neurological and outcome assessment Neurological outcome was collected from the review of the entire hospital record for the admission including the progress notes entered by the intensivist's, nursing and ancillary services, consultation and diagnostic reports, and discharge summaries. The bedside nurse recorded GCS and pupillary response every hour. The presence of status myoclonus, defined as spontaneous or sound 17-DMAG (Alvespimycin) HCl sensitive, repetitive, irregular brief jerks in both face and limb present most of the day within 24 h post-CA was noted.[19] Data on brainstem reflexes (pupillary, corneal, and cough) and motor response to painful stimulus on day 3 were derived from the intensivist's daily documentation of the neurological examination. Families received daily counseling on the clinical condition of the patients. Life-sustaining treatment was withdrawn when requested by the surrogate decision makers following counseling. Brain imaging was not performed for the purpose of prognostication. Continuous EEG monitoring and somatosensory evoked response potential testing was not obtained. CPC was used to define neurological outcome at hospital discharge, which was shown to be a useful surrogate measure of long-term survival[20] [Table 1]. CPC 1, 2 was considered as a favorable and CPC 3, 4, and 5 were considered as an unfavorable neurological outcome.[4,16,20] Table 1 CPC scale Statistical analysis Descriptive statistics are summarized for categorical variables as frequencies (%) and were compared between groups using Fisher's exact test. Continuous variables, expressed as median (inter-quartile range [IQR]), were compared between Selleck BEZ235 groups using Wilcoxon rank sum test. All comparisons were two-sided, and P