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Out of the 64 definite DVT patients, 62 were positive in IRTI (96.88%). Of the IRTI positive cases, 53 (82.81%) had infrared PDC at coincident DVT situs and 9 case (14.52%) did at coincident DVT sides compared with the results of CPUS or angiography. There were highly statistically significant differences both between DVT side and non-DVT side in DVT group (p?selleck chemical thrombosis (DVT), detect, screen. This work was supported by Key Laboratory of Respiratory Disease Foundation for Young Scientists of China, Key Laboratory Foundation of Jilin University Oxygenase and Higher Education Foundation of Guangzhou (Grant No. 2012C220). AKANE KUROKI, TAKAHIRO SATO, ICHIZO TSUJINO, AYAKO IGARASHI, HIROSHI OHIRA, ASUKA YAMADA, TAKU WATANABE, MASARU SUZUKI, SATOSHI KONNO, MASAHARU NISHIMURA First Department of Medicine, Hokkaido University Hospital, Hokkaido, Japan Background?A certain subset of group 3 pulmonary hypertension (PH) patients are known to exhibit advanced, or out-of-proportion, PH. For this population, vasodilator treatment is not generally recommended because of the lack of evidence and possible deterioration of ventilation/perfusion mismatch. Objective?To investigate the efficacy and safety of vasodilator treatment in patients with out-of-proportion group 3 PH. Subjects Since 2010, we have treated 5 consecutive patients with progressive dyspnea due to such PH, using sildenafil alone (n?=?3), sildenafil plus beraprost (n?=?1) or sildenafil plus bosentan (n?=?1). The underlying pulmonary diseases were early-onset chronic obstructive pulmonary disease (n?=?1), rheumatoid arthritis-associated interstitial pneumonia (n?=?1), cystic lung disease (n?=?1) and combined pulmonary fibrosis and emphysema (n?=?2). Results?Before treatment, all patients presented with progressive dyspnea, and demonstrated increased mean pulmonary arterial pressure (MPAP) (44?��?7?mmHg) and pulmonary vascular resistance (PVR) (907?��?177 dyn*s*cm?5). Vasodilator treatment was well-tolerated and, at the follow-up assessment see more 3�C4 months later, all patients noted less dyspnea and significant reduction in MPAP (34?��?5?mmHg, ?22?��?14%) and in PVR (546?��?191?dyn*s*cm?5, ?41?��?11%). Pulmonary oxygenation was deteriorated in 1 patient, but was improved or not significantly changed in the remaining 4 patients. Conclusions?All five patients with progressive group 3 out-of-proportion PH responded favorably to vasodilators. Vasodilator therapy, particularly using sildenafil, may represent a promising option in this population when introduced in the early phase of disease.