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The results indicate little click here pathological evidence of neoplastic activity of small ductal lesions arising in chronic liver disease in their state. However, some cases of VMC have demonstrated a loss of heterozygosity (LOH) using microsatellite markers,[26] and the VMC as a congenital bile duct disorder, not VMC-like duct in virus-related liver disease, may have a premalignant potential to cholangiocarcinoma. In summary, we observed BDA and VMC-like duct, which were small nodular lesions composed of proliferation of ductal or ductular cells, and which resembled the interlobular bile duct or bile ductule and microcystic biliary component in chronic hepatitis and cirrhosis. Based on these pathologic characteristics, we classified the lesions into the following groups: (i) BDA, interlobular bile duct type; (ii) BDA, ductular/peribiliary gland type; and (iii) VMC-like duct. Morphological and phenotypic differences were seen, but the premalignant potential is probably low for small-sized lesions. The authors appreciate the technical support from Ms Matsumoto and the Research Support Center, Graduate School of Medical Sciences, Kyushu University. English Ceftiofur usage in this paper was reviewed by KN international. ""The objective of this study was to investigate the hepatoprotective effect of a bark extract of Bathysa cuspidata extract (BCE) in a murine model of severe liver injury induced by carbon tetrachloride (CCl4). Forty-two Wistar rats were randomized into six selleckchem groups of seven animals each: Group 1(G1): CCl4; Group 2 (G2): dimethyl sulfoxide (DMSO)?+?CCl4; Group 3 (G3): BCE 400?mg/kg alone; Group 4 (G4): BCE 200?mg/kg?+?CCl4; Group 5 (G5): BCE 400?mg/kg?+?CCl4; Group 6 (G6): DMSO alone. The extract was administered by gavage for 18?days beginning 6?days prior to the first application of CCl4. After completing CCl4 administration, the animals were euthanized. The animals in G1, G2, G4 and G5 experienced significant body weight loss and had an increased liver somatic index compared with G3 and G6 (P?