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OSSN has gained interest in the past few years due to its association with the HIV pandemic and it has been observed that increase in incidence of OSSN is collinear with the increase in HIV [10]. With the upsurge of HIV infection, a changing trend in the age of presentation, clinical features and prognosis of patients of OSSN is observed. In this study we aimed to compare Entinostat solubility dmso patient demographics, clinical features and pathological findings in HIV infected and non-HIV population with histologically provenocular surface neoplasia. In particular, our aim of this comparison was to find out any statistically Khaitan2significant difference between clinicopathological features of OSSN in HIV and non-HIV groups. Materials and Methods This was a retrospective study conducted at a tertiary referral center. All the patients, enrolled between April 2009 and March 2014 at M&J Western Regional Institute of Ophthalmology, BJ Medical College, Civil Hospital, Ahmedabad of histologically proven OSSN were included in the study. Data from indoor case records, clinical slit lamp photographs and ocular pathology records of histologically proven cases of OSSN were obtained. All such cases with complete records were included in the study. Patients with OSSN but incomplete records were excluded from the study. A total of 48 cases fully filled our requirement and were finally included in the study. The data was then tabulated under various clinic-pathological headings in HIV affected and non HIV affected groups. Patient details regarding registration number, age of patient, sex, duration of symptoms, vision, fundus details, slit-lamp examination were noted. The details of tumour size, appearance, multifocality, pigmentation, presence of feeder vessel, palpable lymph nodes were noted in every case. The biomicroscopic/morphological appearance of tumour was noted as leukoplakia, papillary, nodular, diffuse or gelatinous. From the ocular pathological laboratory all data regarding detailed histopathological analysis was obtained. All the ocular tumour in the records was graded in mild, moderate and severe dysplasia and well, moderate and poorly differentiated squamous cell carcinoma with severe variants as mucoepidermoid or spindle cell carcinoma. We broadly divided the OSSN cases into two groups carcinoma in situ or the non-invasive tumour and squamous cell carcinoma or the invasive carcinoma on the basis of histopathological data hence obtained for analysis regarding invasiveness of tumour. As all the patients undergoing any surgery at our institute are subjected to HIV Rapid test (COMB.AID HIV1/2) which if found positive is followed by ELISA, hence, status with regards to infection with HIV as positive/negative was easily retrieved and noted. The patient��s awareness of his own HIV status was also recorded either from case records or on telephonic conversation with the patients.