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Data are presented as mean �� SD, medians with minimum and maximum values and frequencies as appropriate. Annual incidence per 100?000 children was calculated by dividing the number of valid cases diagnosed in any given year by the at-risk population. Trends buy 3-deazaneplanocin A over time were estimated using univariable linear regression models using year of diagnosis as the independent variable. Reported are estimates of change per year and their standard error. Seasonal trends were estimated by calculating the binomial probability of the number of cases observed in each calendar month assuming equal distribution of cases throughout the year. Differences between patients initially admitted at high-caseload hospitals versus low-caseload hospitals were assessed using Fisher's exact test and Student's t-test. All statistical analyses were performed using SAS Statistical Software v9.1 (SAS Institute, Cary, NC, USA). A total of 2378 patients were reported over the 4 surveillances, with a significant increase in the number of patients reported during each consecutive surveillance. We observed an important year-to-year variation in the number of patients reported. The overall annual KD incidence for children 0�C4 years of age significantly increased over time from 14.4/100?000 in 1995�C1997 to 26.2/100?000 in 2004�C2006 (P Erastin both estimates were available, and showed an increase in annual KD incidence in children 0�C4 years old from 2.8/100?000 in 1979 to 24.1/100?000 in 2004. As expected, the incidence was highest in children 0�C4 years of age (73% of cases) and significantly decreased thereafter (Table?1). The incidence of both complete and incomplete KD was found to increase over time, but the incidence of incomplete KD had a faster increase than that of complete KD (+0.35 cases/100?000 per year incomplete KD more than complete KD, P Ro3280 The 1.62?:?1 male?:?female ratio was consistent across all age groups (Fig.?2). There were no differences in the demographic characteristics of patients reported in each of the 4 surveillances. We observed a prominent seasonal distribution of cases (Fig.?3), with the highest caseload reported from November to March (14�C31% higher than average, P