The Thing You Don't Know About GDC-0449 Will Probably Surprise You

His anterior fontanel was tense and bulging. Computed tomography of brain showed a well-defined, heterogeneously enhancing lesion in the pineal region (Fig. 1A, B). Magnetic resonance (MR) imaging revealed 6.1��6.2��7.2 cm lesion with epicenter in the pineal region. It showed mixed intensity on T1 (Fig. 1C), T2 (Fig. 1D) weighted sequences with peripheral cystic areas. The lesion was heterogeneously enhancing (Fig. 1E) and causing triventricular hydrocephalus. Diffusion weighted MR image revealed restricted diffusion suggestive GDC-0449 of high cellularity (Fig. 1F). Gradient recovery echo sequence of MR showed multiple dark signal intensities in the tumor suggestive of calcification and absence of blooming effect of hemorrhage (Fig. 1G). The patient was subjected to right ventriculo-peritoneal shunt followed by excision of tumor in the second stage. The patient underwent surgery by the supracerebellar infratentorial selleck chemicals llc approach. The tumor was firm, gritty and vascular. Near total excision of the tumor was done, in which posterior and central part of tumor was excised and shell of tumor anterolaterally left behind. The patient had a stormy postoperative course and succumbed due to septicemia. Fig. 1 Radiology of the tumor. A: Plain computed tomography of brain showing a well-defined, heterogenous lesion in the pineal region. B: Post contrast computed tomography showing patchy heterogenous enhancement of the lesion. Magnetic resonance (MR) imaging ... Pathological findings The specimen of tumor showed multiple firm, Quinapyramine white glistening tissue bits aggregating to 8 cm and with punctate brown black pigmentation on the cut surface (Fig. 1H). The histopathological examination showed a nodular architecture with nodlarge, focally crowded, and occasional binucleate cells were seen. Hyaline cartilage was seen focally (Fig. 2A-E). The tumor was sampled in toto and did not reveal any primitive neuroepithelial areas or rosettes in neither the surgical specimen nor post mortem specimen. Post mortem examination of the brain revealed a shell of residual tumor anterolaterally without clots in the pineal region (Fig. 2F). Immunohistochemistry showed that the glial cells in the nodules were positive for glial fibrillary acidic protein; the large ganglion cells were positive for synaptophysin but negative for CD34. The meningothelial like cells were positive for vimentin but negative for epithelial membrane antigen. MiB1 labelling index was