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We developed key standards of care to evaluate and manage S.?aureus bacteraemia, which comprised: obtaining blood for follow-up cultures within 5?days; administration of at least 14?days of antibiotic therapy for the bacteraemia; and investigation for infective endocarditis by echocardiography. Further evaluations, such as radiographic studies, were recommended to the attending physicians if clinical resolution was delayed regardless of appropriate antibiotic therapy. Practical 14- and 28-day regimens for uncomplicated and complicated patients, respectively, were determined on the basis of current guidelines and recent literature [14�C16]. However, because the optimal treatment and appropriate classification of S.?aureus bacteraemia remain Sitaxentan undefined, we established 14?days as the minimal duration of therapy. We reviewed the numbers of blood cultures received by the laboratory from any patients MK-8776 in vivo during the study period and the trends of all consultations recorded by the Department of Infection Control and Prevention in a database, as indicators of general effects on laboratory use and liaison with IDPs. Each consultation record was classified as ��consultation with attending physician��, ��significant laboratory results��, ��antibiotic prescription�� and ��other�� when the intervention started. For bivariate analyses, categorical variables were compared by Fisher��s exact test and an unpaired t-test where appropriate. The cumulative survival time between the day of the first blood culture results that were positive for S.?aureus and death or the last outpatient clinic visit during the study period was calculated by the Kaplan�CMeier method for all Quizartinib molecular weight patients. The difference in 30-day cumulative survival of patients was tested by the Mantel�CCox test. The potential factors associated with 30-day mortality of patients were examined by the Cox proportional hazards regression analysis. All covariates that differed significantly between the initial intervention period and the later intervention period in the bivariate analysis were considered for model entry into the above mentioned multivariate analyses. Data were analyzed with pasw for windows, version 18.0 (SPSS Inc., Chicago, IL, USA). All p values were two-tailed and p?