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These children were referred from the general outpatient department of the hospital after obtaining a thyroid profile for symptoms suggestive of CH. Data related to age at diagnosis, gender, parental age, family history, thyroid scintigraphy, ultrasonography and thyroid hormonal levels were recorded. The diagnosis of TD was based on the findings of Technetium-99m pertechnetate thyroid scintiscan and thyroid ultrasonograms done at the time of initial evaluation of CH. The diagnosis of hypothyroidism was based on low serum total T4 levels and elevated serum TSH levels according to reference ranges (5). Those having subclinical hypothyroidism, autoimmune thyroiditis selleck kinase inhibitor or syndromic diagnosis like Down syndrome (DS) were excluded. Maternal and paternal ages at the time of child birth were determined by subtracting the child��s age from the parental ages at the time of diagnosis. Maternal ages were compared with the normative data presented in a previous Indian study (6). The logistic regression analysis was performed to find out the independent predictive ability of maternal age for the binary outcome of TD. Pearson��s correlation was used to analyse correlations among various quantitative study variables investigated. Tasisulam Comparisons of maternal ages with normative data were made by the student��s independent t-test. A p-value of �� 0.05 was considered as statistically significant. All the statistical analyses were performed on Statistical Package for Social Sciences (SPSS Inc., Chicago, IL, version 18.0 for Windows). Results Complete information on thyroid scintigraphy and ultrasonography was available in 80 out of 310 children referred to our Pediatric Endocrinology Clinic with a diagnosis of CH over the study period. Majority (63, 78.7%) had agenesis of thyroid gland followed by ectopic gland in 12 (15%) and hypoplasia in 5 (6.2%) patients. In ultrasound, agenesis was detected in 70 (87.5%) Inhibitor Library and ectopia and hypoplasia each in 5 (6.2%) patients. There were 40 (50%) boys and 40 (50%) girls (male to female ratio 1:1). They were born at term gestation and had average birth weights. Their mean age (SD) at diagnosis was 2.65 (2.81) yrs (range 2 mo to 11 yrs). The mean initial total T4 and TSH concentrations in these children were 2.705 �� 2.384 ��g/dL (range 0.01�C8.9) and 293.48 �� 289.81 mIU/L (range 10.03�C1159.0) respectively. Mean maternal age (SD) of 25.87 (4.17) yrs (range 19�C35 yrs) was significantly higher as compared with the mean maternal age (SD) of 23.87 (3.34) yrs (range 18�C39 yrs) in a reference population (p