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Results:? Three hundred and forty-nine patients had GETE ratings available at Weeks 16 and 32 (omalizumab n?=?258, OAT n?=?91). Omalizumab responders of about 171/187 (91.4%)and Dabigatran 44/71 (62.0%) omalizumab nonresponders at Week 16 persisted as responders or nonresponders at Week 32. The investigator��s GETE at Week 16 predicted persistency of response or nonresponse to omalizumab at Week 32 for 83.3% (215/258) of patients. OAT patients showed a lower persistency of response (18/28 [64.3%]) and a higher persistency of nonresponse (57/63 [90.5%]) than omalizumab patients. Excellent and good GETE ratings in omalizumab-treated patients were reflected by improvements in exacerbation rates (P?Bortezomib ic50 as assessed by a physician��s GETE at 16?weeks, is an effective predictor of continuing persistent response to omalizumab for the majority of patients. Omalizumab is a humanized anti-immunoglobulin E (IgE) monoclonal antibody approved as add-on therapy for the treatment of adults and adolescents with inadequately controlled severe (European Union [EU]) or moderate-to-severe (USA) allergic (IgE-mediated) asthma (1, 2). In the EU, the indication has recently been extended to include children (6 to Selumetinib price to omalizumab based on pretreatment characteristics (7). Evidence suggests that omalizumab may be more effective in patients in whom disease-specific IgE levels account for a low proportion of total IgE (8�C10); however, neither total nor specific IgE was found to have consistent predictive value for omalizumab response (10). A pooled analysis of five studies found the physician��s global evaluation of treatment effectiveness (GETE) following 16?weeks of omalizumab therapy to be the most meaningful measure of response. The physician��s GETE is a composite measure that encompasses multiple aspects of evaluation of response, including patient interviews, review of medical notes, spirometry and diaries of symptoms, rescue medication use, and peak expiratory flow (PEF) (7). Patients judged by the physician to have shown complete asthma control or a marked improvement in asthma control are classified as treatment responders. Patients showing discernible but limited control, no appreciable change or a worsening in control are classified as treatment nonresponders. The 16-week evaluation period is consistent with the mechanism of action of omalizumab.