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9 mm Hg) (solid line) compared to patients with high MAP (75-89.9 mm Hg) (dotted line). To ensure that the MAP was maintained in excess of 65 mm Hg in our study patients, we used fluid perfusions and vasopressors. The number of patients receiving vasopressors in the low MAP group was significantly higher than in the high MAP group. The mean dosage for each vasopressor used did not differ between the two groups. Norepinephrine alone or combined with dopamine was used in most patients (Table 3). Table 3 A univariate analysis of the effect of vasopressor administration in patients with AHRF under mechanical ventilation Discussion To clarify the relationship between MAP observed over the first 24 hours of admission and the 60-day mortality rate, and ICU STI571 solubility dmso outcomes in patients with AHRF, we performed a subgroup analysis of a prospective, multicenter study UNC2881 in 22 ICUs. We divided the patients that fulfilled our study criteria into two groups according to MAP over the first 24-hour post-admission; a low MAP group (65-74.9 mm Hg), and high MAP group (75-90 mm Hg). We found that there was no difference in 60-day mortality rates between the patients with high and low MAP. Several other studies have used a range of 65-85 mm Hg as an MAP target for the resuscitation of septic shock patients8,9. In our study, the MAP over the first 24 hours was 69.6 mm Hg and 80.4 mm Hg for the low and high MAP groups, respectively. Additionally, in several clinical trials that enrolled patients with ALI or ARDS under mechanical ventilation, the baseline MAP at the time of admission was approximately 76-77 mm Hg. They aimed to maintain admission MAP over the first 24 hours post-admission17,18. However, the optimal arterial blood pressure level in mechanically ventilated AHRF patients is not well known. Therefore, we used an MAP of 65-74.9 mm Hg as a target range, as recommended by the surviving sepsis campaign19 and 75-90 mm Hg as a high range of MAP. In a study conducted by Asfar et al.20, they showed that the mortality rate of septic shock patients was not related with the MAP. They found the 28-day mortality rate for the high target group (MAP, 80-85 mm Hg) to be 36.6%, and 34.0% for low target group (MAP, 65-70 mm Hg)20. Our study showed that the mortality rates of mechanically ventilated AP24534 ic50 patients did not change in relation to MAP, when maintained above 65 mm Hg. We found 60-day mortality rates in patients with an MAP of 65-74.9 mm Hg to be 26.2%, and 24.5% in patients with an MAP of 75-90 mm Hg, with no statistically significant difference between them. In the present study, the percentage of patients under vasopressor therapy was lower (42%) than previous randomized trials on ARDS patents (73%)21. Furthermore, in the high MAP group in our study, less than 20% of patients received vasopressor therapy. Multivariate analysis showed vasopressor therapy was not related with 60-day mortality in this study.