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127 total BMD Z-score per each 12 months, R2?=?0.999, p?Cilengitide �inconsistent� �due to� �several� methodological �issues�, �including� �incomplete� �examination of� �the subjects�, �lack of� �prospective� �studies�, �and� �undoubtedly� �the fact that� �most of the� �previous� �studies� �were� �performed� �among� long-term �survivors�. �Our� �study� �focused on� BMD �within the� �first� �5 years� �following� �therapy�. �With the exception of� �the male� predominance �in the� �NHL� �group�, �the� �clinical� �and� �treatment� �variables� �were� �typical� �for the� �expected� �populations� �of� �childhood� lymphoma �survivors� [9], [10]?and?[11]. �The� �mean� �age of� �the children� �studied� �in the� �NHL� �group� �was� �lower than� �that� �noted� �in the� �HD� �survivors�, �and this� �may have� �accounted for� �higher� �absolute� �values� �of� BMC �and� BMD �among the� �older� �individuals�. �Furthermore�, �we� �did not� �find� �any� �differences� �between� �height and weight� �variables� �in the� �study� �population� (�in either� �the absolute� �values� �or the� Z-scores), �which are� �considered� �the most important� �determinants� �of� �bone� �status� �in children�. �We� �did not� �observe� �differences� �between� BMC �and� BMD �expressed� �as� Z-scores, �even after� �adjusting� �for� �age� �and� �gender�. �Finally�, �we� �found� �only a� �minimum� �support� �for the� �occurrence� �of� BMD �deficits� �amongst� �our� �study� �participants� �C �a� �finding� �contradictory� �to� �conclusions� Everolimus in vivo �of� �other� �studies� �that� �previously� �reported� �apparent� �low� �bone� �mass� �in childhood� �cancer� Palbociclib �survivors� [2]?and?[12]. �On the other hand�, �some of those� �published� �data� �reported� �negligible� �or� �minimum� BMD �deficits� �especially in� �pediatric� �HD� �survivors� [3]. �It has been� �reported� �that� �low� BMD �rates are� �observed� �mostly� �during the� �first� �2 years� �after ALL� �and� �NHL� �treatment� [12], [13], [14]?and?[15]. �According to� �some� �data�, �the� BMD �in� �HD� �and� �NHL� �survivors� �was� �normal� �for a� �short time� �after� �completion of� �therapy� �or� �was� �reduced� �only� �slightly� [2]?and?[4]. �In our� �study�, �no� �difference in� �the� BMD Z-scores �was� �seen� �after� �division� �of the� �whole� lymphoma �group�, �in accordance with the� �time� �interval� �that had� �passed� �since the� cessation �of� �therapy�. �Although� �no� �significant� �age� �difference between� �those� subgroups �was� �noted� (�those� �examined� �later� �being� �older�), �it is possible� that�Cif �the� �sample� �size� �was� �larger� �C �the difference� �in� �age� �would� �turn� �significant� �and this� �could affect� �comparisons� �between the� �2� �groups�. �In� lymphoma �survivors�, �steroid� �use� �may be� �an important factor� �predisposing� �for� �developing� �bone� �mineral� �deficits�, �especially when� �the medication is� �administered� �in� �high� �cumulative� �doses� (>9000?mg/m2) [13]?and?[16]. Within our research, the final doses found in a variety of treatment methods were found to become nor significantly diverse not impacting on the particular BMD.