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Although the results suggested an association between the SNP ?384A/C in LIPG and CAD in a Han Chinese population, there are still several limitations. First, the population size in this study is limited. A total of 287 patients with CAD and 367 control individuals were recruited in the study. Second, the disease phenotype was not divided into subcategories. As the exact functions of the lipid metabolism in the pathogenesis of various CAD are unclear, we decided to combine all categories of CAD and got a positive result. Third, LIPG belongs to the TG lipase gene family and its preferred substrate is HDL-C; however, the SNP ?384A/C was not associated with the HDL-C level in this study. The reason may lie in the compensation of other lipases. Additionally, the significant differences in TG and TC in different genotype groups suggest other potential ways in which LIPG attends to lipid metabolism. Conclusion To the best of our knowledge, this study is the first case�Ccontrol study on the association of the SNP ?384A/C of LIPG with CAD in a Han Chinese population. Our results suggested that the ?384A/C variation in LIPG may be a genetic risk factor for CAD and further functional analysis to elucidate the role of LIPG in CAD is needed. Acknowledgments This study was funded by ��The Grants from Ministry of Education of China��(313037), Program for Changjiang Scholars and Innovative Research Team in University ��PCSIRT�� (this website IRT0935), Research Project from Health Department of Sichuan Province (130114) and Nature Science Foundation of China (81401238). Footnotes Contributors: LX, YS and YD conceived and designed the experiments. LX, YS and YD performed the experiments. LX, YL, YT and YD analysed the data. LX, YS and YD wrote the paper. Funding: This study was funded by The Grants from Ministry of Education of China (313037), Program for Changjiang Scholars and Innovative Research Team in University ��PCSIRT�� (IRT0935), Research Project from Health Department of Sichuan Province (130114) and Nature Science Foundation of China (81401238). Competing interests: None declared. Ethics approval: The study was approved by the Ethics Committee of Sichuan University. Provenance and peer review: Not commissioned; externally peer reviewed. Data sharing statement: No additional data are available.""An important objective of health agencies worldwide is to protect children from passive smoking that results from family members smoking in the home.1 Thus, the promotion of home-based non-smoking policies is the key to tobacco control programmes because it not only reduces a child's exposure to secondhand smoke but also increases smoking cessation rates.2 However, very few Asian countries have reported similar estimates.