Those Things Every Individual Ought To Know Concerning Sulfatase

As can be seen from Table 1, the dosage of UVA used has varied from centre to centre. There has now been a move towards 5?J/cm2 as the standard and doses well below this may be adequate to elicit positive photopatch test reactions (54�C57). Higher doses e.g. 10?J/cm2 lead to a greater risk of leading to phototoxic reactions, and are also more time consuming (19, 55). Testing photopatches in triplicate (UVB, UVA and control) is also reported previously (58, 59). Also described in France is triplicate [Polychromatic (UVB, UVA, Visible), UVA and control] (16, 43, 44). There are occasional reports www.selleckchem.com/products/Adriamycin.html of photosensitizers that appear to have absorbance and action spectra only in the UVB wavelengths (52, 60). However, with wavelengths DAPT in vivo by UVA irradiation alone and suggested that the use of UVA as the sole source of radiation seems justified (61). In this study, the authors also demonstrated that no late positive PACD reactions were seen when readings were performed 5 days post-irradiation, which were not present at 2 days post-irradiation (61). When recording results of reactions, grading scales have been adopted locally and do bear similarity to one another (40, 41). However, with the increasing Sulfatase need to compare results between centres, the scale used by the International Contact Dermatitis Research Group (ICDRG) has gained a more widespread acceptance (62). When positive reactions are seen, it is useful to attempt to determine their relevance with respect to the problem that the patient presented with. The COADEX (C = current; O = old/past; A = active sensitization; D = unknown; E = history of exposure; X = cross-reaction) system is one such system that can be used (63). With such a wide range of different methodologies, the comparison of study findings between publications has been difficult. Accordingly, there have been attempts at standardization (40, 45, 46, 48). The most recent pan-European consensus methodology has been published under the auspices of the European Society of Contact Dermatitis and the European Society for Photodermatology (64). An agreement was reached that suspected agents be applied for 24 or 48?h followed by irradiation with 5?J/cm2 of broad spectrum UVA (PUVA tube lights) followed by readings at 24, 48 and, if possible, 72?h. Using such a methodology in the United Kingdom produced evidence of PACD to a new compound when investigating nine organic UV filters, one proprietary sunscreen ��as is��, and patients' own products (65). Of 1155 patients tested, 66 (5.7%) had PACD to at least one agent.