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Unpaired Student��s t-test or the Mann�CWhitney test as appropriate, were used to determine significant differences of continuous variables between the two study groups. Mortality-free survival was examined using the Kaplan�CMeier estimator. All p-values were two-tailed. P-value find more patients with MR was reduced after TAVI from 58 (85.3%) to 43 (63.2%), p?Oxymatrine Only one patient (1.5%) experienced worsening of the MR grade (from moderate to severe). See Table 1 and Fig. 1. Vena contracta width was decreased from 0.47?��?0.28 to 0.25?��?0.21, p?=?0.043. Patients�� demographic and clinical characteristics by post-procedure MR improvement are summarized in Table 2. About 42% of both groups had organic MR, and the average EuroScore (used to assess surgical risk in the studied cohort) was 23.1?��?16.4. MR improvement was not associated with MR etiology (48.1% in organic vs. 48.6% in functional, p?=?0.968) nor operative risk (50.0% in EuroScore >20 vs. 48.6% in EuroScore Tenofovir chemical structure 54.2% in CoreValve compared to 43.9% in Edwards (p?=?0.424), and was 51.2% in femoral approach compared to 41.7% in transapical approach (p?=?0.457). Both the peak and mean pressure gradients across the aortic valve were similarly improved among patients with and without MR improvement. The reduction in pulmonary artery pressure after the procedure was seen more commonly among patients with MR improvement (8.3?��?13.8 vs. 0.7?��?14.0?mmHg, p?=?0.049). LV ejection fraction did not change among patients with or without MR improvement (?1.5?��?7.1 vs. 0.8?��?7.2?mmHg, p?=?0.214).