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These management strategies should be based on a multidisciplinary team approach. There is evidence to suggest there may be a transient increase in breast cancer during the first 3�C4 years following pregnancy.3�C5 In a population-based prospective study of 802 457 Norwegian women aged 20�C56 years,5 a short-term increase in breast cancer after full-term pregnancy was observed, Ergoloid with a peak 3�C4 years after the delivery. Early menarche and late age at first pregnancy are also associated with an increased risk of breast cancer.6 Pregnancy also increases the risk of breast cancer developing in carriers of BRCA1 and BRCA2 mutations. Carriers of these mutations who have children are significantly more likely to develop breast cancer by the age of 40 years than carriers who are nulliparous, with each pregnancy being associated with an increased risk of cancer.7 Having a baby at a young age does not appear to protect BRCA1/BRCA2 carriers against subsequent development of breast cancer.8 Most invasive breast cancers are classified as invasive ductal carcinoma not otherwise specified (IDC NOS), AC220 whereas about 25% are defined as histological ��special types��.9 Axillary lymph node involvement is observed in two-thirds of pregnant women with breast cancer.10,11 A large proportion of breast tumours diagnosed during pregnancy are high grade and display lymphovascular invasion.10,11 selleck compound The incidence of positive estrogen and progesterone receptors is often found to be low (