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On multivariate analysis, all factors apart from serum ALP and PPC remained independently predictive of a positive bone scan. The strongest correlation with a positive scan was a serum PSA of > 20 ng/mL (P Sunitinib concentration analysis DISCUSSION The purpose of this study was to explore of predicting factors of positive scan in prostate cancer patients. These factors which were introduced in previous reports are presented in Table 4. Table 4 Predicting factors of a positive Fossariinae scan introduced in previous reports Following the introduction of PSA, the test soon became the most commonly utilized prognostic parameter in prostate cancer. Using PSA cut-offs alone, we found the negative predictive value of a serum PSA PI3K Inhibitor Library significant difference was noted in the ALP levels of patients with and without bone metastasis (P = 0.24; HR, 1.3 [95% CI, 0.7-3.1]). The current results revealed that bone metastasis is common in Turkish patients with newly diagnosed, untreated prostate carcinoma, with an overall positive rate of %20 (44/220) on bone scans. The positive rate is approximately double that reported recently reported in the United States (8.9%) and same in Japan.[13,14] The greater metastasis rate compared to these studies may be due to different sampling methods. Recent studies demonstrated Gleason grade to be a predictor of bone scans in prostate cancer like pre-treatment PSA values.[15,16] The overall proportion of positive scans was significantly higher in patients with GS ��7 compared to those with GS