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Results:?There was no significant difference in percentage area of the epithelium stained for pSmad2/3 between the COPD-CS and Normal-NS groups (median values 7.87 vs 7.34, respectively; p?=?0.9). However, pSmad2/3 stained vessels in the Rbm were increased in the COPD-CS group compared to controls (median values 5.08 vs 2.46, respectively; p?Selinexor mouse have to be working through ��alternative�� pathways. LEE A1,2,3, MCDONALD C2,4, MAHAL A5, HILL C2,4, BURGE A1, MOORE R4, NDONGO R3, COX N3, LAHHAM A3, NICOLSON C1, O'HALLARON P3, HOLLAND A1,2,3 1Alfred Health, 2Institute for Breathing and Sleep, 3La Trobe University, 4Austin Health, 5Monash University Introduction:?Self-efficacy describes an individual's coping skills and may influence the outcomes of pulmonary rehabilitation, but the relationship between self-efficacy, functional status and health-related quality of life in people Selleckchem RGFP966 with chronic obstructive pulmonary disease (COPD) is unclear. Aim:?To describe the relationship between self-efficacy and measures of functional exercise capacity, symptoms, mood and health-related quality of life in people with COPD. Method:?Participants with COPD undergoing initial assessment at commencement of an 8-week home- or hospital-based pulmonary rehabilitation programme completed the Pulmonary Rehabilitation Adapted Index of Self-Efficacy (PRAISE), with scores ranging from 15 to 60 and higher scores indicating greater self-efficacy. Disease severity was classified according to the Global Initiative for COPD (GOLD) criteria. 3-mercaptopyruvate sulfurtransferase Exercise capacity was measured using the 6-minute walk distance (6MWD). Other measures included the modified Medical Research Council (mMRC) dyspnoea scale, the Chronic Respiratory Disease Questionnaire (CRDQ) and the Hospital Anxiety and Depression scale (HADS). Results:?One hundred and thirty-three participants (mean age 71[SD9] years and FEV1 49.5[19.1]% predicted) were included. Mean (SD) PRAISE score was 47(9.2) points, and ranged from 15 to 60. Lower self-efficacy was associated with a greater level of functional dyspnoea according to the mMRC (p?=?0.04) but was unrelated to the 6MWD (r?=?0.02, p?=?0.81), age (r?=?0.27, p?=?0.43) and gender (p?=?0.37). Self-efficacy did not differ according to disease severity based on GOLD criteria (p?=?0.18). Worse scores on the PRAISE were associated with significantly greater fatigue and worse mastery on the CRDQ, but correlations were weak (r?=?0.25�C0.27). Lower self-efficacy correlated fairly with depression (r?=??0.395, p?