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6, range?=?69�C131) but a reduction in processing speed (Table?2). There were significant deficits in immediate and delayed visual memory (which survived Bonferroni correction), despite preserved auditory memory. Executive function deficits were also seen in verbal fluency, inhibition switching, the BADS tests and the trail making task. Performance on the naming learn more task was significantly impaired (Table?2). Using graph theoretical analysis, we showed that the WM structural networks of both groups exhibited a much higher local interconnectivity of the nodes (normalized clustering coefficient, ��???1) (JME group: mean?=?3.72, SD?=?0.38; control group: mean?=?3.86, SD?=?0.60) and an equivalent shortest path length between any pair of nodes (normalized path length, ��?��?1) (JME group: mean?=?1.03, SD?=?0.04; control group: mean?=?1.03, SD?=?0.05), compared with the matched random networks. The small-worldness (��?=?��/��) calculated from these indices was also larger than 1 (JME group: mean?=?3.61, SD?=?0.44; control group: mean?=?3.77, SD?=?0.85). Furthermore, these three metrics did not differ between patients and healthy controls (all ps?>?0.10). In summary, JME patients displayed prominent small-world values close to the values of the brain network of healthy controls. Structural network tuclazepam analysis estimated for patients and controls revealed that both groups exhibit hubs. In particular, 21 hub regions were shared by both groups, including the precuneus, superior parietal gyrus, postcentral gyrus, superior frontal gyrus, superior occipital gyrus, and left middle occipital gyrus. These hubs are located predominantly in regions of association cortex that receive convergent inputs from multiple cortical http://www.selleck.co.jp/products/Docetaxel(Taxotere).html regions. Of note, more brain regions were identified as hub regions in the patient group. These regions comprised the left orbitofrontal gyrus, left paracentral lobule, left inferior temporal gyrus, right middle temporal gyrus, left putamen, and left cerebellar lobule Crus I, and right cerebellar lobule Crus 2. Using two-sample t-tests, no significant between-group differences were identified for the four global network measures investigated (clustering coefficient, global efficiency, characteristic path length, and betweenness centrality) (all ps?>?0.05). The absence of these group effects suggests that global connectivity is relatively intact in JME patients. Between group-differences were identified in the nodal (region-specific) efficiency, indicating local connectivity alterations in the JME group. Specifically, compared with the controls, the nodal efficiency in the left postcentral gyrus (pcorr?