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The diagnosis and classification of GVHD was conducted according to the previous consensus [6,7]. IFI was regarded as the primary cause of death when the patient died of progressive organ failure, in which IFI was first found in the absence of other comorbidities, excluding GVHD. The following variables were recorded and analysed: gender, age, type of underlying disease, underlying disease status, number of mismatched HLA loci (A/B/DRB1), neutrophil engraftment time, platelet engraftment time, previous history of IFI, antifungal prophylaxis, acute GVHD, chronic ISRIB datasheet GVHD, reactivation of cytomegalovirus, and relapse of underlying disease. Statistical analyses were performed with SPSS?13.0 software. Grouped variables were compared by use of the chi-squared test, and continuous variables were compared by use of the non-parametric Mann�CWhitney test. Risk factors were analysed with a Cox proportional hazard model. Acute GVHD and chronic GVHD see more were regarded as time-dependent variables. The Kaplan�CMeier curve was used to present survival curves, and the cumulative incidence was analysed for competing risk with R software. A p-value of 7�C180?days). The CYTH4 cumulative incidence rates for acute GVHD of grades?II�CIV or III�CIV at 100?days after transplantation were 47% and 14.7%, respectively. The 255 patients who survived for more than 100?days were evaluated for chronic GVHD, and the cumulative incidence rates of limited and extensive chronic GVHD at 3?years were 33.3% and 23.1%, respectively. The cumulative relapse rate at 3?years was 16.2%. The overall survival rate at 3?years was 64.6%, and the survival rate of the standard-risk group was significantly higher than that of the high-risk group (68.4% vs. 49.1%, respectively, p?0.002). Peripheral blood lymphocytes were detected at fixed time-points (Fig.?1). Although the CD4+ cell count gradually recovered, the absolute CD4+ cell number was