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Post hoc (Tukey) testing showed that the TBI group performed significantly worse than the controls on the sway-referenced conditions (all p's?selleck kinase inhibitor score (average across all four conditions) from the Equitest system also differed significantly between the TBI patients (mean?=?67.1%; range 46.3�C84.0%) and the controls (mean?=?77.0%; range 66.6�C82.7%), t(22)?=???2.69, p?Obeticholic Acid concentration supported by higher absolute clustering coefficients, and global integration, supported by shorter absolute path lengths. This balance of global and local connectivity was abnormally shifted toward the global end of the scale in TBI patients. This could be quantified by a change in the small-worldness parameter ��. Although networks in both groups were small-world (��?>?1), indicating that they had generally greater-than-random clustering (��?>>?1) (TBI group: mean?=?5.94, SD?=?1.71; control group: mean?=?3.88, SD?=?0.32), but near-random path length (��?��?1) (TBI group: mean?=?1.01, SD?=?0.06; control group: mean?=?1.04, SD?=?0.02), small-worldness was marginally increased [F(1,25)?=?5.41, p?Methisazone TBI group. Using ANOVA's with age and density as covariate, we observed that the TBI group showed decreased values of local efficiency [F(1,25)?=?10.46, pcorr?