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9, p Ock call [��2(2) = 2.2, p = 0.32]. Sensitivity of A1 neurons to ILD�Cdiscrimination index and modulation range We characterized the discrimination quality afforded by the ILD sensitivity of http://www.selleckchem.com/erk.html A1 cells by calculating DIs and the modulation range of firing rates over the test ILD range. Figure ?Figure55 illustrates the distributions of DIs (Column A) and the modulation range of spike rates (Column B) for the four stimuli. The modulation range and DI were computed at each cell's optimal level (ABLopt), which was defined as follows: if the within-level analysis (One-Way ANOVA) revealed only one ABL with significant ILD sensitivity, that ABL was defined as ABLopt. Otherwise, the ABL with the highest DI was defined as ABLopt. Therefore, data points in each sub-panel of Figure ?Figure55 are independent, as each cell is only represented once at the ABLopt. Note that the DI calculation does not make any assumptions about the shape of the sensitivity function; therefore, ILD-insensitive (p > 0.05) cells simply have low DIs, reflecting the experimental observations. The distributions of ABIopt for each stimulus are shown in Table Onalespib nmr ?Table1;1; this distribution was significantly dependent on stimulus [��2(6) = 28.7, p > 0.0001]: for the pure tone, the number of cells at ABLopt is relatively consistent, whereas, this number increases with ABL especially for the Tsik and Twitter calls, where more cells have ABIopt of 70 dB. Figure 5 Discrimination index (DI) and modulation range. Column (A) shows the distribution of DI ABLopt for all stimulus types. Column (B) shows the distribution Cisplatin of modulation range with respect to changes in ILD at the ABLopt. Shading of bars in both columns ... The mean (��SEM) DIs for the CF tone, and the Ock, Tsik and Twitter calls were 0.3990 �� 0.0098, 0.4016 �� 0.0099, 0.3668 �� 0.0103, and 0.3483 �� 0.0094, respectively (Figure ?(Figure5,5, Column A), significant differences were found between groups (p