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These areas include the amygdala, reuniens thalamic nucleus, and raphe nucleus. Note that despite weak inputs, the rabies labeling of these neurons is as clear as the labeling of neurons in the areas that provide strong synaptic inputs, due to the self-replication of rabies viral cores in MI-773 cost presynaptic neurons and subsequent strong expression of mCherry (Wickersham et?al., 2007a). We then mapped circuit connections to a mixed population of CA1 inhibitory neuron types using Dlx5/6-Cre mice (Monory et?al., 2006), in which selective Cre expression is targeted to forebrain GABAergic neurons. As expected, spatially restricted AAV and EnvA rabies viral injections infected a small population of different inhibitory cells located in different CA1 laminae (Figures 3A, 3C, 3D, and S2), with the average numbers of starter cells?being 47.75 �� 9.48, 38.35 �� 2.59, 11.25 �� 4.40, and 9.75 �� 4.53 (n?= 4 cases; Table S1B) for the stratum oriens (SO), stratum pyramidale (SP), stratum radiatum (SR), and Oxalosuccinic acid stratum lacunosum-moleculare (SLM), respectively. These mixed CA1 inhibitory cell types had strong input connections from putative excitatory cells located in the SP of CA1, with a CSI of 9.72 �� 0.49. Overall, the CA1 inhibitory neurons and excitatory pyramidal cells have a similar connectivity pattern of extrinsic CA1 sources, but different connection strengths (Figure?S5A; Tables S1A and S1B). The Ponatinib supplier CSIs of inhibitory cell types for ipsilateral CA2 and ipsilateral and contralateral CA3 are 0.17 �� 0.01, 1.63?�� 0.37, and 0.60 �� 0.18, respectively, which differ significantly from those of pyramidal cells (p?