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All patients were able to complete HIIT sessions at the targeted intensity (80% of MAP for peaks). No adverse events were noted during HIIT training. There were no changes in medications related to cardiovascular risk factors during the program. The mean number of sessions per week was not different between the two groups (3.3?��?1 and 2.9?��?0.8 in MICE and HIIT groups, respectively; P?=?0.4), and all patients performed at least the two main sessions per week. Table 1 describes the clinical characteristics of both groups at baseline. Briefly, patients had similar age and weight, however BMI, LDL- and HDL-cholesterol were all significantly lower in the MICE group. In contrast, the MICE group had a marked elevation in triglycerides (TG), whereas TG levels were normal in the HIIT group. The prevalence of abdominal obesity, hypertension, Resminostat and abnormalities of glucose metabolism was not significantly different between groups. Myocardial repolarization parameters are shown in Table 2. QTd, QTcd and rdQT were significantly lower in the MICE group at baseline. After the intervention, all QTd parameters significantly decreased in both groups, except for sdQT. Table 3 describes the cardiometabolic risk factors at baseline and after the 9-month program. Bodyweight and BMI were significantly reduced in both groups, this reduction being greater in the HIIT group, while WC and diastolic blood pressure significantly see more decreased only in HIIT group. HDL-, LDL-cholesterol and TG also significantly decreased in both groups, with a greater reduction in TG and TG/HDL ratio in the MICE group. Prevalence of MetS and its components before and after the intervention are illustrated in Fig. 1: the prevalence of MetS significantly decreased in MICE (from 30 to 26 patients, P?Staurosporine solubility dmso (both groups) and hypertension (HIIT group only). Maximal exercise testing data are reported in Table 4. There was no difference in training compliance between the two groups, and exercise capacity significantly increased in both groups (+0.82 METs and +1.25 METs in MICE and HIIT groups respectively, both P?