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This identified a significant main effect of genotype (p?find protocol full in Inline Supplementary Table S5. Post-hoc analyses demonstrated that this interaction was due to s/s and l/l CA+ individuals showing no difference in neural reactivity in this region, whereas s/s CA? individuals demonstrated significantly higher neural reactivity compared to l/l individuals. Inline Supplementary Table S5 Table?S5. Whole brain effects (no covariates): threshold at p?U0126 concentration s/s individuals demonstrated higher neural reactivity compared to l/l individuals, was reduced (p?=?0.099 FWE corrected) following inclusion of the covariates (see Fig.?4b). However, a more dorsal region of the left cuneus (BA19) demonstrated significantly higher activation in l/l compared to s/s individuals crotamiton (p?=?0.008 FWE corrected) (see Fig.?4a). This change in the pattern of activation is likely due to the effect of genotype on RNLE14 score (see Participant questionnaire associations section above). However the main effect of CA was no longer significant at p?