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Hips subject to Perthes disease had poorer lateral coverage by the acetabulum, but a larger head (��?=??0.65, p?32?mm. Conversely, the data for hips subject to Perthes disease extended into the region of healthy hips, so many hips subject to Perthes disease developed a BML-190 normal angle and a normal head. Poor lateral head coverage increased the contact hip stress and the stress gradient index, while an articular sphere with a large effective radius decreased the contact hip stress and the gradient index. Opposing effects resulted in no significant difference in contact hip stress (Table 3), but the stress gradient and the position of the stress pole were less favorable in the test group (Table 3), the pole laying significantly more laterally (Table 3) resulting in a steeper stress distribution over the load bearing area. Accordingly, the angle that spanned this area was significantly smaller in the test group. However, because of the larger effective radius of the articular surface, the load-bearing area Af was not different (with indecisive power 1???��?=?0.63). Both populations had the same dependence (albeit in different regions) of hip stress gradient index on the effective radius of the articular surface (A) and on the center-edge angle (B), indicating that the underlying mechanism is the same for all hips (Fig. 4). A majority of healthy hips had a negative Gp, Doxorubicin in vitro while many hips with Perthes disease had a positive Gp. The correlation coefficients for the Gp(r) and Gp(?CE) dependences were ?0.58 and 0.95, respectively (p?DAPT We were interested in non-specific biomechanical parameters, so we included all hips as a single group, regardless of how they were treated (operatively or conservatively). Hips with Perthes disease had smaller center-edge angles (Table 3, Fig. 3), which would increase peak stress. However, they had larger effective radii of the articular surface at load bearing, which would decrease peak stress. The two effects canceled each other, so no difference existed in peak stress between Perthes and healthy hips. However, hips with Perthes disease had a less favorable (steeper) distribution of contact stress over the load bearing area, reflected in the more lateral position of the stress pole, a larger stress gradient index, and a smaller span of the load bearing area.