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mRNA (left panel) and protein content (right panel) ... Myogenesis and cell proliferation markers In the posttest mRNA contents of MyoD (+113%), Myf5 (+100%), and Myogenin (+63%) were higher than in the pretest (P Dabigatran of needle biopsying on key markers in skeletal myogenesis and cell proliferation. Data are means �� SEM (n = 9) and are expressed as fold increase relative to the baseline obtained from the pretest biopsies. mRNA content was measured in ... Mitochondrial biogenesis markers Compared with the pretest, mRNA contents of TFAM (+87%) and PPAR�\�� (+50%) were elevated in the posttest, but for TFAM this only occurred in the proximal biopsy (P Alpelisib manufacturer ?(Fig.7).7). PGC�\1�� content significantly changed at neither biopsy site although a trend toward an increased content at the proximal biopsy site was observed (P = 0.10). mRNA contents were different between the distal and proximal biopsies for both PGC�\1�� and TFAM. Figure 7. Effect of needle biopsying on key markers in mitochondrial biogenesis and regulation. Data are means �� SEM (n = 9) and are expressed as fold increase relative to the baseline obtained from the pretest biopsies. mRNA content was measured in muscle ... Protein synthesis and breakdown markers mRNA contents of MURF�\1 (approximately +60%), BNIP�\3 (approximately Bosutinib +160%), and Akt�\1 (approximately +65%) were increased in the posttest in both the distal and proximal biopsies (P