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11.15. Antitumour Activity Antitumour activity of ethanol extract Pandanus was evaluated against Dalton's ascitic lymphoma (DAL) tumour model on dose-dependent manner. The activity was assessed using survival time, average increase in body weight haematological parameters, and solid tumour volume. Oral administration of alcoholic Pandanus extract increased the survival time and decreased the average body weight of the tumour bearing mice. After 14 days of inoculation, EPF was able to reverse the changes in the haematological parameters, protein and PCV FMO5 consequent to tumour inoculation. Oral administration of EPF was effective in reducing solid tumour mass development induced by DAL cells. The results showed that EPF possess significant activity in dose-dependent Bafilomycin A1 manner [46]. 11.16. CNS-Depressant Action The effect of methanolic extract of P. odoratissimus leaf on the CNS was studied by using different neuropharmacological paradigms including spontaneous motor activity, rota-rod performance, and potentiation of Pentobarbital sodium sleeping time in albino mice. Preliminary phytochemical evaluation and acute toxicity studies were also carried out where LD50 > 2000?mg/kg was considered nontoxic through acute exposure in rats by the oral route. The Pandanus extract (50, 100, and 200?mg/kg i.p.) produced a reduction in spontaneous motor activity, motor coordination and prolonged Pentobarbital sodium sleeping time. These observations Selleck PF-06463922 suggest that the leaf of P. odoratissimus contains some active principles which possess potential CNS-depressant action [8]. 11.17. Antiepileptic/Anticonvulsant Activity Increase in latency to seizures as well as reduction in duration and frequency of seizures indicated anticonvulsant activity. The selected extract was more effective in all models used except the strychnine-induced convulsions. P. odoratissimus ethanol extract (100 and 200?mg/kg body wt.) significantly (P