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One implant was deemed mobile at the time of inspection. Clinical conditions were acceptable with 11% of the implants showing pockets?��?5?mm. Periodontopathogens were encountered frequently and in high numbers. Clinical parameters and bacterial levels were highly patient dependent. The mean bone level was 2.30?mm (SD 1.53; range 0.00�C6.95), with 23% of the implants demonstrating advanced resorption (bone level?>?3?mm). Regression analysis showed a significant association of the patient (p?Ritonavir peri-implant bone loss is rather common and indicative of graft resorption. This phenomenon is patient dependent and seems also associated with oral hygiene. ""To elucidate the influence of initial soft tissue thickness on peri-implant selleckchem bone remodeling. The research hypothesis was that implants installed in patients or at sites with thin mucosal tissues would show increased peri-implant bone loss. 79 edentulous patients were consecutively treated with two non-splinted implants supporting an overdenture in the mandible. During recall-visits, peri-implant health was determined by means of probing pocket depth and the modified plaque/bleeding index. Digital peri-apical radiographs were taken from individual implants. Bone level changes were measured from a reference check details point (lower border of the smooth implant collar) to the marginal bone-to-implant contact level. The linear mixed-effect model analysis was adopted to analyze the influence of clinical parameters and transmucosal abutment height on peri-implant bone loss. 67 patients attended the 1-year and 66 the 2-year recall-visit. Mean bone level changes were 0.89?mm (SD 0.62) and 0.90?mm (SD 0.66), plaque scores 0.82 (SD 0.94) and 0.87 (SD 0.92), bleeding scores 0.46 (SD 0.68) and 0.56 (SD 0.72) and PPD 1.65?mm (SD 0.60) and 1.78?mm (SD 0.59) after 1 year and 2 years respectively. The linear mixed-effect model revealed increasing bone level changes with decreasing abutment heights. Peri-implant bone level changes were significantly higher for implants with abutments of