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9?�� 0.5 versus 4.9?�� 1.5?nmol/l, p?Antiinfection Compound Library manufacturer about the insulin sensitivity of human BAT, we assessed the influence of insulin on BAT, WAT, and skeletal muscle glucose uptake (Figure?1D). The insulin-stimulated glucose uptake rate in the supraclavicular adipose tissue (Figure?1C), identified to contain cold-activated BAT, was 5-fold higher than when studied without insulin stimulation (0.9?�� 0.4 versus 4.7?�� 2.4?��mol/100 g/min, p?ATP7A 0.1?��mol/100 g/min) similar to that in subcutaneous abdominal WAT. BAT is highly vascularized. The blood flow provides oxygen for BAT mitochondria, and also transfers heat from BAT to other parts of the body. We quantified perfusion in supraclavicular BAT, subcutaneous neck WAT, and skeletal muscle (Figures 2A�C2C). The BAT perfusion more than doubled in response to cold (7.5?�� 3.7 versus 15.9?�� 4.9?ml/100 NU7441 clinical trial g/min, p?= 0.0002), while no changes were observed in subcutaneous WAT (3.0?�� 1.6 versus 3.7?�� 2.0?ml/100 g/min, p?= 0.18) or in skeletal muscle (3.8?�� 3.6 versus 2.0?�� 1.1?ml/100 g/min, p?= 0.08) (Figure?2D). Subsequently, glucose extraction from blood was determined (Figure?2E). Cold exposure increased glucose extraction from blood in BAT (0.1?�� 0.1 versus 0.6?�� 0.2?��mol/ml, p?= 0.004), but not in subcutaneous WAT. The glucose extraction in skeletal muscle was also slightly increased by cold exposure (0.3?�� 0.1 versus 0.4?�� 0.2?��mol/ml, p?= 0.03). The glucose uptake rate and perfusion in the supraclavicular adipose tissue were associated in a curvilinear fashion during cold exposure (r?= 0.822, p?