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""Abstract:? Breast cancers in Turkey tend to be diagnosed at advanced stages due to lack of organized comprehensive mammographic screening. In this study, factors associated with having a mammogram among healthy women of screening age in Bahcesehir county, a region in Istanbul, were investigated to assess the feasibility of organized breast cancer screening RhoC in Turkey. In this cross-sectional study, 659 healthy women aged between 40 and 69?years were surveyed. A multiple-choice questionnaire was used to obtain information regarding patient demographics, family history of cancer, and patient knowledge on mammographic screening. Factors associated with increased likelihood of having a mammogram included age older than 50 (OR?=?1.75; 95% CI?=?1.23�C2.49), higher educational level (high school or university graduate; OR?=?1.55; 95% CI?=?1.07�C2.25), and undergoing periodic gynecologic examinations (OR?=?5.53; 95% CI?= 3.88�C7.89). Women aged between 40 and 49 years, who were most likely to have a mammogram Z-VAD-FMK solubility dmso within the last 2?years were characterized by a higher educational level (OR?=?1.94; 95% CI?=?1.14�C3.31), periodic gynecologic examinations (OR?=?4.06; 95% CI?=?2.53�C6.51), and a first or second degree family history of breast cancer (OR?=?2.2; 95% CI?= 1.06�C4.50). In contrast, women aged between 50 and 69?years were more likely to have undergone mammography within the previous 2?years if they also had undergone periodic gynecologic examinations (OR?=?8.63; 5.04�C14.77). Our http://www.selleckchem.com/products/ly2157299.html findings suggest that women of lower educational level and those who do not undergo routine wellness visits with their gynecologist will need to be specifically targeted for educational outreach to achieve broad screening compliance within the population. ""Upon disease progression on trastuzumab-based therapy, patients with HER-2 positive metastatic breast cancer (MBC) may switch to lapatinib or continue on trastuzumab. We aimed to assess the impact of both strategies on overall survival (OS) in all patients treated for HER-2 positive MBC at the Medical University Vienna from 1999 until 2009. A total of 201 patients were identified from a breast cancer data base. Of these 115 (57.2%) received multiple lines of trastuzumab-based therapy, whereas 58 (28.9%) were treated with a single line. A control group of 28 patients (13.9%) had never received trastuzumab as they were treated before 1999, when trastuzumab was registered. OS from diagnosis of metastatic disease was defined as primary study endpoint. Trastuzumab significantly prolonged OS in HER-2 positive MBC (41 versus 13?months; p?