What You Should Find Out About YES1 And The Actual Reason Why

95 (95% CI 0.92�C0.96). On the basis of these values, PPV and NPV were 0.98 (95% CI 0.97�C1.00) and 0.75 (95% CI 0.74�C0.76), respectively. Fagan plot analysis demonstrated that this method was very informative, with 94% probability of correctly detecting click here dengue following a ��positive�� measurement when the pre-test probability was 25% and lowering the probability of disease to as low as 9% with a ��negative�� measurement. This diagnosis would be wrong in 24% and 48% of patients with a ��negative�� measurement when the pre-test probability was 50% and 75%, respectively, although the probability of a correct diagnosis following a ��positive�� measurement equaled 98% and 99% for dengue, respectively (Table 4). Nine studies evaluated the diagnostic accuracy of the commercial kits Dengue NS1 Ag STRIP Kit and SD BIOLINE Dengue Duo Strip Kit for dengue (Table 2). The sensitivity and specificity of diagnosis for dengue ranged from 48% (95% CI 38�C59%) to 90% (95% CI 87�C93%) and 93% (95% CI 87�C96%) to 100% (95% CI 93�C100%), respectively. The summarized sensitivity and specificity were 71% (95% CI 61�C79%) and 99% (95% CI 98�C100%), respectively. The summarized diagnostic OR was 328 (95% CI 103�C1046) and HSROC was 0.96 (95% CI 0.95�C0.98) (Figure 2B). On the basis of these values, PPV and NPV were 0.99 (95% CI 0.98�C1.00) and 0.75 (95% CI 0.75�C0.76), respectively. There was statistically significant heterogeneity in diagnostic OR (Q?=?17.05, p?YES1 these two kits for detecting dengue was affected by study design and publication year, selleck kinase inhibitor while the result was not changed (data not shown). Publication bias existed among these studies (p?=?0.02). Fagan plot analysis demonstrated that the method of immunochromatography was very informative, with 97% probability of correctly detecting dengue following a ��positive�� measurement when the pre-test probability was 25% and lowering the probability of disease to as low as 9% with a ��negative�� measurement. This diagnosis would be wrong in 23% and 52% of patients with a ��negative�� measurement when the pre-test probability was 50% and 75%, respectively, although the probability of a correct diagnosis following a ��positive�� measurement equaled 99% and 100% for dengue, respectively (Table 4, Figure 4). Eight studies evaluated the diagnostic accuracy of the commercial kit Dengue NS1 Ag STRIP Kit for dengue (Table 2 and Table 4). The summarized sensitivity and specificity were 71% (95% CI 64�C82%) and 99% (95% CI 98�C100%), respectively. The summarized diagnostic OR was 486 (95% CI 124�C1902) and HSROC was 0.96 (95% CI 0.94�C0.98). On the basis of these values, PPV and NPV were 0.99 (95% CI 0.98�C1.00) and 0.78 (95% CI 0.77�C0.78), respectively.