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A bootstrapping on the �� coefficient and SEs was performed with 200 replications. Additionally, we compare our prediction model with two different cardiac risk stratification systems: the European System for Cardiac Operative Risk Evaluation (EuroSCORE) and Parsonnet score. Assumptions were assessed using different techniques. Multicollinearity was assessed using the Pearson correlation statistics and the variance inflation factor (VIF). Highly correlated variables, for example, renal failure and dialysis, patients with Alectinib nmr diabetes and patients with insulin dependency were not combined into a single model. Moreover, influential cases are computed using Cook's distance. A case is said to be influential in logistic regression if its Cook's distance is >1.0.15 As a rule of thumb in logistic regression, there should be at least 10 events per predictor to obtain reliable estimates of regression coefficients as suggested by Hosmer and Lemeshow.15 Inspection of candidate predictors revealed that some complications had rare events (PI3K inhibitors in clinical trials and clinical characteristics Table?1 presents patient, surgery and LOS characteristics. The majority of patients were men (69.7%), 13% of the patients being older than 70?years, and there were 12 octogenarians in the dataset. The mean age of cardiac surgical patients was 58.6?years. The mean age of patients who underwent isolated CABG was 59.3, valve surgery 53, combined surgery procedures 64.2 and other types 55.3. Patients aged 40?years or younger constituted 5.6% Tryptophan synthase for CABG, 5% for valve surgery, 6.7% for combined CABG plus valve surgery and 5.3% for other types of surgeries. Table?1 Demographic and perioperative characteristics The 75th centiles of the CICU LOS and postoperative LOS were 5?days and 11?days, respectively. The study group used a total of 2816 cardiac ICU patients days. Patients with prolonged postoperative LOS (183 patients) had 60% of the total patients days. Only 5% of the patients who underwent cardiac surgery were discharged by the 5th postoperative day. The majority of the patients (61%) were discharged between 6 and 10 postoperative days. In total, 45% of the patients undergoing heart surgery had diabetes mellitus. Hypertension was prevalent in 67% of the patients. There were 229 patients who had CHF. Nearly 27% of the patients had unstable angina and 6.3% were diagnosed with atrial fibrillation. Approximately 12% of the patients had renal failure preoperatively; among these patients, only 1.3% were on dialysis. Based on BMI as used by the WHO,16 patients were either underweight (