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The mechanism of preterm labor is not clear, thereby hindering the development of successful preventive methods and making large practice variation for treatment of TPL. TPL has been defined as the presence of at least 3 regular and painful uterine contractions within a 30-minute period [15], or the presence of at least two uterine contractions every 10 min for 60 minutes, in combination with cervical changes ascertained on digital examination, and/or cervical length find more is known to involve regular painful uterine contractions accompanied by cervical changes. However, other clinical manifestations such as vaginal bleeding, mild or irregular contraction, menstrual-like cramping, PPROM, and short cervix that may overlap with true preterm labor, can hamper the clinical discrimination between true preterm labor and TPL. It is not easy to discriminate true preterm labor from TPL in clinical field. As most Isoxsuprine women presenting with TPL are at an increased the risk of preterm birth, they are usually admitted. Thus, pregnant women with TPL were enrolled in this study, though they might not have true preterm labor. Present treatments in TPL focus on the inhibition of preterm uterine contractions, at the end point of the cascade of the pathophysiological process. The treatment of women at risk of preterm delivery consists of administration of tocolytic drugs for 48 hours to allow for administration of corticosteroids and transportation of the patient to a center with NICU facilities in case if gestational age is Bcl-2 apoptosis pathway in preterm labor with intact membranes in the absence of overt signs of infection [19]. It is unknown that in utero exposure of various antibiotics is safe on the preterm neonate. Nevertheless, the patterns of antibiotics use for TPL were quiet variable, and treatment duration was about 5 to 6 days in Korea. Based on this study, the rate of antibiotics use was very high in preterm labor with intact membranes. It is needed that the antibiotics use is restricted to specific cases such as chorioamnionitis, cervical infection.