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To determine the effect of low-dose aspirin on neonatal mortality and morbidity. Neonatal intensive care unit admission; Intraventricular haemorrhage (IVH) grade II or above��defined as bleeding into the ventricles Grade II (moderate)��IVH occupies 50% of the lateral ventricle volume, Grade IV (severe)��haemorrhagic infarction in periventricular white matter ipsilateral to a large IVH; Ventilation��defined as need of positive pressure (continuous positive airway pressure (CPAP) or nasal CPAP) or intubation; LGK974 Neonatal sepsis��confirmed bacteraemia in cultures; Anaemia��defined as low haemoglobin and/or haematocrit requiring blood transfusion; Respiratory distress syndrome��defined as need of surfactant and ventilation as a result of prematurity; Necrotising enterocolitis (NEC) requiring surgical intervention; NEC is defined by a combination of clinical, radiological and laboratory features: Systemic signs��apnoea, bradycardia, temperature instability, hypotension. Intestinal signs��abdominal distension, gastric residuals, bloody stools, absent bowel sounds, abdominal tenderness, peritonitis. Radiological signs��pneumatosis intestinalis or portal venous air, pneumoperitoneum. Laboratory changes��metabolic and or respiratory acidosis, thrombocytopaenia, disseminated Ebastine intravascular coagulation. Composite of any of the above. To determine the effect of low-dose aspirin on the incidence of neonatal birth weight below the 3rd, 5th and 10th centiles. Birth weight will be recorded in the participants' medical notes, and birthweight percentile for gestational age at delivery is calculated using a normal range derived from our population.25 To determine the effect of low-dose aspirin on the incidence of stillbirth or neonatal death. Owing to any cause; Ascribed to PE or FGR; In association with maternal or neonatal bleeding. To determine the effect of low-dose aspirin on the incidence of spontaneous preterm delivery at selleck chemicals llc in Spain; and one in each of Milan, Brussels, Greece and Israel. Design There are three components to the study: an internal pilot study, a screening quality study and a screening study followed by a double-blinded randomised placebo-controlled trial. Informed consent will be obtained by a trained healthcare professional who is a member of the study team at each particular centre. Internal pilot study The main study has been preceded by a 2-month pilot study, undertaken at King's College Hospital. In total, 1106 participants have been consented into the screening study and 56 participants to the randomised controlled trial (RCT).