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Variables Exposure variables Maternal risk factors included were age at birth of the cohort child, smoking status during pregnancy (yes/no), multiparity (previous pregnancies lasting >20?weeks or first birth used as a surrogate measure for having elder siblings at home; yes/no) and index of socioeconomic disadvantage of the mother's residential postcode at birth. We also included child factors: sex, plurality of click here birth (multiple birth or singleton; yes/no), mode of delivery (normal vaginal delivery; yes/no), need for oxygen supplementation at birth (yes/no) and birth during the first half of RSV season (yes/no, born between 1 April and 30 June or not, as the RSV season in NSW is generally between April and September). Outcome variable The outcome variable of interest was any episode of RSV-coded hospitalisation in the cohort child in the first 2?years of life. The International Classification of Diseases, 10th edition (ICD-10), primary diagnostic codes were used to identify RSV hospitalisations. All hospitalisations coded as RSV pneumonia (J12.1), acute RSV bronchitis (J20.5) and acute RSV bronchiolitis (J21.0) were included as RSV hospitalisations. Data sources The data relating to the exposure variables were retrieved from the PDC. The corresponding 17-AAG hospitalisation history/outcome variable for each cohort child identified in the PDC was collected from the linked APDC. Socioeconomic disadvantage was measured using the SEIFA (Socioeconomic index of areas) Indices of Relative Socioeconomic Advantage and Disadvantage (IRSAD) from the Australian Bureau of Statistics.14 Bias This was a large whole-of-population-based study with minimum selection bias. We used only RSV-coded hospitalisations and not laboratory confirmed RSV hospitalisation, which may have led to underestimation of number of events. RSV is not routinely tested in NSW, which does not allow estimation of laboratory confirmed RSV-associated hospitalisation at a population level. Furthermore, our previous analysis from this cohort12 has shown that all the RSV-coded hospitalisations were recorded during the RSV season, so it is likely that we captured the majority Ebastine of episodes of RSV hospitalisations in this cohort. Study size This was a whole-of-population study including all children born in NSW between 2001 and 2010, so we did not perform any sample size calculation for our study. Quantitative variables Maternal age at birth of the cohort child was divided into five age groups including age