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At the time of the study, the mean value of serum creatinine was 1.2?mg/dL (range 0.6�C3). The main clinical comorbidities are shown in Table?1. Regarding viruses, a very low level of quantitative EBV�CPCR (104?copies/mL). In this group, two of nine had a new onset of EBV while the others were chronically EBV positive with a low viral load. Two of nine children developed PTLD: an 11-yr-old boy had intestinal localization of PTLD, while in a 10-yr-old girl it started from Waldeyer's ring. A three-yr-old girl presented with severe clinical signs of mononucleosis. Six of nine children were asymptomatic and in two of them, who were chronically EBV positive, we discovered a laboratory finding of MGUS (Fig.?1). In both PI3K inhibitor patients with MGUS, immunofixation electrophoresis showed the presence of IgG �� monoclonal free light chains. The occurrence of MGUS was concomitant with the de novo onset of a progressive increase in EBV viral load (Time 0). In these patients, real-time PCR for all others viruses, including CMV, was negative or showed a low viral load (JQ1 research buy significant increase in EBV load, we suggested a net reduction in the CNI dosage, and Fig.?2 shows the behavior of viral load in respect to immunosuppressive modulation. A month after the reduction in immunosuppressive therapy, we firstly recorded a significant reduction in the viral load and after about four months, the MGUS disappeared in both children. In the subsequent follow-up, too, when (T12) the viral load increased again and in the long term, the reappearance of MG was no longer recorded. The main IRS1 clinical data of the two patients with MGUS are shown in Table?2. The prevalence of MGUS increases with age. The mean age at diagnosis is about 70?yr, and