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While cytosine methylation has been widely studied in extant species, relatively few studies have attempted to analyze epigenetic marks in the DNA of ancient or extinct organisms
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While inhibition affected two samples (E5.1 and C34-1) enough that it may have contributed to the higher variance in percent methylation observed in those samples
While not proving it, such findings are consistent with FT011's ability to inhibit the biological activities of TGF-b1 and thereby the expression of osteopontin and consequent macrophage infiltration
While the exact crosstalk between SIRT3 and PGC-1a is still currently being actively investigated SIRT3 encourages the expression of PGC-1a
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